Research, all articles

Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study

07/12/2017

ABSTRACT Rodent studies demonstrate that supplementing the maternal diet with choline during pregnancy produces life-long cognitive benefits for the offspring. In contrast, the two experimental studies examining cognitive effects of maternal choline supplementation in humans produced...

Eggs early in complementary feeding increase choline pathway biomarkers and DHA: a randomized controlled trial in Ecuador

01/11/2017

Abstract Background Choline status has been associated with stunting among young children. Findings from this study showed that an egg intervention improved linear growth by a length-for-age z score of 0.63. Objective We aimed to test the efficacy of eggs introduced early in complementary...

Maternal IgG immune complexes induce food allergen–specific tolerance in offspring

20/11/2017

Abstract The role of maternal immune responses in tolerance induction is poorly understood. To study whether maternal allergen sensitization affects offspring susceptibility to food allergy, we epicutaneously sensitized female mice with ovalbumin (OVA) followed by epicutaneous...

Effects of maternal dietary egg intake during early lactation on human milk ovalbumin concentration: a randomized controlled trial

07/10/2016

Abstract Background: There is limited understanding of how maternal diet affects breastmilk food allergen concentrations, and whether exposure to allergens through this route influences the development of infant oral tolerance or sensitization. Objective: To investigate how maternal...

Early life innate immune signatures of persistent food allergy

24/10/2017

Abstract Background Food allergy naturally resolves in a proportion of food allergic children without intervention, however the underlying mechanisms governing the persistence or resolution of food allergy in childhood are not understood. Objectives This study aimed to define the innate...

AMA Recommendations Highlight Importance of Choline for Pregnancy

28/06/2017

Abstract The American Medical Association (AMA) recently announced its recommendation to include choline in prenatal vitamins.1 Choline is an essential nutrient that is particularly important during pregnancy, as it impacts fetal brain development and can help prevent birth defects.2...

Suboptimal Maternal Iodine Intake Is Associated with Impaired Child Neurodevelopment at 3 Years of Age in the Norwegian Mother and Child Cohort Study

01/07/2017

Abstract Background Severe iodine deficiency in pregnancy has major effects on child neurodevelopment, but less is known about the potential consequences of mild-to-moderate deficiency and iodine supplement use. Objective We explored the associations between maternal iodine intake and...

Timing of food introduction and development of food sensitization in a prospective birth cohort

29/05/2017

Abstract Background The effect of infant feeding practices on the development of food allergy remains controversial. We examined the relationship between timing and patterns of food introduction and sensitization to foods at age 1 year in the Canadian Healthy Infant Longitudinal...

Eggs in Early Complementary Feeding and Child Growth: A Randomized Controlled Trial

30/05/2017

Abstract Background Eggs are a good source of nutrients for growth and development. We hypothesized that introducing eggs early during complementary feeding would improve child nutrition. Method A randomized controlled trial was conducted in Cotopaxi Province, Ecuador, from March to...

Randomized controlled trial of early regular egg intake to prevent egg allergy

20/08/2016

Abstract Background The ideal age to introduce egg into the infant diet has been debated for the past 2 decades in the context of rising rates of egg allergy. Objective We sought to determine whether regular consumption of egg protein from age 4 to 6 months reduces the risk of IgE-mediated...