Brain / cognitive health

Maternal Dietary Choline Status Influences Brain Grey and White Matter Development in Young Pigs

21/03/2018

Abstract Background Choline is an essential nutrient that is pivotal to proper brain development. Research in animal models suggests that perinatal choline deficiency influences neuron development in the hippocampus and cortex, yet these observations require invasive techniques. Objective...

Macular Xanthophylls Are Related to Intellectual Ability among Adults with Overweight and Obesity

20/03/2018

Abstract Excess adiposity or obesity has been inversely related to cognitive function and macular xanthophyll status. However, whether the neuroprotective effects of macular xanthophylls on cognitive function are independent of excess adiposity is unclear. We investigated the relationship...

Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations

08/01/2019

Ramon Velazquez, Eric Ferreira, Wendy Winslow, Nikhil Dave, Ignazio S. Piras, Marcus Naymik, Matthew J. Huentelman, An Tran, Antonella Caccamo & Salvatore Oddo Abstract The lack of effective treatments for Alzheimer’s disease (AD) is alarming, considering the number of people currently...

Choline: The Underconsumed and Underappreciated Essential Nutrient

01/11/2018

Wallace, Taylor C., PhD, CFS, FACN; Blusztajn, Jan Krzysztof, PhD; Caudill, Marie A., PhD, RD; Klatt, Kevin C., MS; Natker, Elana, MS, RD; Zeisel, Steven H., MD, PhD; Zelman, Kathleen M., MPH, RD, LD Wallace Taylor C, Blusztajn Krzysztof J et al, 1 November 2018, Choline: The Underconsumed...

Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations. Velazquez R, et al. Mol Psychiatry. 2019; Epub ahead of print.

08/01/2019

Abstract The lack of effective treatments for Alzheimer's disease (AD) is alarming, considering the number of people currently affected by this disorder and the projected increase over the next few decades. Elevated homocysteine (Hcy) levels double the risk of developing AD. Choline, a...